After Ultron was taken out by the new generation of Avengers, they stumble upon a group of children who were the children of other super heroes, villains and members of S.H.I.E.L.D along with a few surviving mutants.
When the robots left in Ultron's city start getting out of hand and a new evil arises, it's up for the two groups to band together to team up to ensure their survival and the survival of the rest of the world
Not connected with Avengers Infinity War, Avengers Endgame