The Legacy of Pandora's Box

Two siblings discover Pandora's box... The little sister tells her brother to keep it a secret and never open it.. Five years pass and the brother, out of curosity, Opens the box.. How the two siblings handle this situatuion.. And how will the world handle It?
Cover: http://hanromi.deviantart.com/art/Angel-Pandora-s-Box-390404895