Rosalina is reunited with her childhood friends, Vergil and Dante, twin brothers who are nephilim, after years under torture of Mundus. She is now fighting against him with the organization called the order which is created by Vergil. Vergil teams up Rosalina with Dante to take down Mundus' powerful corporations that run Limbo City and the world. Being with Dante, Rosalina feelings starts to grow more with Dante including Dante's feelings for her but he doesn't want to show it because he is afraid that she would be hurt because of him. While the duo are making good progress, Rosalina starts to have suspicions on Vergil because of his behavior with Kat and towards rest of humanity. And yet, the trio come across a mysterious woman named Lunadea. She, in her own way, has wormed her way into the trio's minds and plans. She needs the twins for their power to take down Mundus. But is that all she needs? Who's the hero, the true villain, and the neutral one? Based on the DmC: Devil May Cry game (2013)