In a dystopian future, after an epidemic erases all women, the government begins experimenting with fertile boys in an attempt to keep the human race going. After escaping from his holding facility, a young "Mother" named Ryeowook happens upon an isolated farm where he seeks refuge and meets Yesung, Kyuhyun, and Donghae. When Yesung finds out Ryeowook's traumatic secret, he agrees to help Ryeowook rescue the other "Mothers" and expose the government's horrors.