A mysterious agent with incredible strength and speed, Ace, helps the organization Project Hope track down monstrous humans called Hunters and fight against the opposing secret organization, Mettalion. They are the ones responsible for the Hunters and a number of other inhumane experiments and tests. Ace hates them with a passion, but who he is won't make any sense until his new manager, Sparrow, with her bodyguard Angel, team up with him to face Mettalion's best and worst.