The year is 2289 the Enclave is falling rapidly into a doomed state, ever since the sole Survivor destroyed the Institute he has been leading a path of destruction from Boston with the brotherhood of steel. They have already destroyed many bases and scattered groups in the states: South Carolina, North Carolina, Virginia and many others. The next target is the biggest (yet small do to the lack of manpower the enclave have) base in Alabama, in the ruins of Birmingham. You are following the story of John Daniels a seventeen year old yet high ranking enclave soldier, born in the year 2272.