Being a superhero sometimes means you forget about the small dangers in the world, like disease. For Peter, this means he loses May to natural causes, not something he could ever save her from. Unknown to him, May left custody of Peter in the hands of Tony Stark, who, even though he wants kids, has no idea how to actually raise one. With a grieving superhero teenager on his hands, Tony is going to have to figure it out quick, if he wants Peter to ever be able to move on and be happy.