After Pete Wentz and The Chicago Vampire Hunters, Patrick Stump, Joe Trohman, and Andy Hurley defeat the four different vampire gangs of Chicago, The Goths, The Punks, The Vampires of the Hood and The Dandies they get arrested but little do they know, the officers too are vampires. Rogue vampires set out with ill intentions to stop Pete and his gang of hunters. Pete despises vampires as he was forced to become one against his own will. There aren't many like him and his small group of hunters. Most who aren't vampires just cower in fear of those who are and keep their distance as best as they can. Chicago has become more vampire and less human over the course of time The Hunters have spent in the Chicago prison. With each day feeling longer than the last they all continue arguing over how they're going to be able to break out. Pete can't do much of anything to quicken their plans except for giving input as the guards have weakened his vampire strength to that of an average human's strength. Anything he tries while the guards aren't watching doesn't work, forcing him and his partners to become more frustrated. How will they get out and stop this already rapidly spreading problem before it's too late?