Seth MacFarlane is a young college student in his final year at the Rhode Island School of Design studying film and animation. One day, transfer student from Pace University Leah Sinatra, niece of the famed Frank who is also studying film and animation, walks into Seth's class and its love at first sight for the pair of cartoonists. They go through dinners with embarrassing parents (especially Ron and Perry MacFarlane), movie nights and Sinatra-fests. But then Seth gets a offer that will change his life for ever, and where does that leave Leah?