her2 cd3 bispecific

Recombinant Anti-TNF & Anti-IL17A Bispecific Antibody (DVD-Ig).The DVD-Ig format that was used comprised a whole TNF-binding 'IgG' (with Fc region) to which additional variable regions that bind IL17A were fused 'on top' of the existing variable regions. The complex is capable of blocking TNF as well as IL17A simultaneously. bsAb-mediated simultaneous interference with two (or more) RTK signaling pathways, by inactivating either the RTKs or their ligand, should reduce the possibility of such escape mechanisms and, hence, improve therapeutic efficacyinhibiting their signaling and suppressing tumor cells growth. It was designed for the treatment of Plaque psoriasis.