Amelia is in this on and off, complicated, relationship with her best friend Mark Sloan. They've been on and off and on and off for years, it's hard to even keep track. Owen, on the other hand, just got out of a toxic marriage with Cristina Yang because she accused him of being in love with Amelia Shepherd, which she wasn't wrong. Owen did love Amelia- well maybe love isn't the right word, but he thought she was insanely pretty. Owen wanted a good relationship, and he wanted to be with Amelia, but she was with someone else. At the same time Amelia becomes tired with the complicated on and off relationship with Mark Sloan, so maybe she'll try something new?