For long as people can remember in Townsville, The Powerpuff Girls have protected the city from crimes and the forces of evil. Even if new villains rise and even if old villains have something new on their sleeves, the Powerpuff Girls always step up their game to save the world before bedtime. But now, the Powerpuff Girls are investigating the defeats of their villains and crimes by another individual team with powers and even technologies to fight them through forces that labeled as 'vigilantes'. Who are those new individual team? Where did they come from? And why they fight as 'vigilantes'? One thing for sure, the Powerpuff Girls will have to face their greatest challenge when a new threat rise to destroy the world and only they and the 'vigilantes' will have to work together to defend their homes. 'Defenders, Engage!!' Sequel to the Powerpuff Girls Rules!! A parody of 'The Avengers MCU'