guy Friday- noun a man who acts as a general assistant in a business office or to an executive and has a wide variety of especially secretarial and clerical duties. GUY FRIDAY: The man who helps you with everything, more of a servant than a friend, but still your bro Guy Friday noun : an efficient and devoted aide or employee : a right-hand man I am one of the top personal assistants in Los Angeles. People hire me for a day, year, and everything in-between. I own my own company, Guy Friday. A freelance personal assistant. Clients refer to me as Guy or Friday. Around the clock, twenty-four seven, and paid up front. Download the app on i-tunes.