Izaya has always been alone. Nobody liked him for his entire life, except for the people who pretended to be friends with him only for benefits. His only actual 'friend' had left him for a headless demonic creature, and his own sisters try to kill him. Izaya never had anyone to depend on, and had always kept to himself. Nobody would be able to change that, and nobody would be able to see past his barriers. Eccedentesiast: The meaning of someone who hides pain behind a smile.