What if when Odin ordered Frigga out of the room when her son was at his trial after the events of "The Avengers", Frigga refused to leave. She demanded to be at Loki's side.
When Loki crashes on Amanda's date, she doesn't forget. Niece of Tony Stark, she seeks out her uncle and ends up staying with him for most of her life. When she gets to be an intern at S.H.I.E.L.D., she gets put in charge of Loki. With Thanos giving her nightmares, there is a threat of another attack. She trains with the Avengers and gets weapons of her own. Will getting to know and being in charge of Loki change her mind of this super-villain?