It's a story of two people who have an unexplained hatred for one another. They can't stand being in the same room with each other. They've met purely in coincidence, taste of one druken night at their bestfriend's wedding. Caleb Buendia, a misygony who hates women happens to impregnate Cleo Sacramento, a misandry who hates men. He hates her. She hates him more. How are they going to hold each other claws away from one another for the sake of their unborn child? Paano nga ba sila magkakasundo? Saan ba magsisimula ang kanilang pag-iibigan, dahil ba sa magiging anak nila o ang pintig na ng puso nila ang pumili para sa isa't-isa. Whatever, It's their 'Perfect Mistake'.