Sheridan Whiteside has been friends with Maggie Cutler for ten years. But when a simple slip lands them both in the household of an Ohio family for four weeks, Maggie finds something she thinks is a little bit more important. Threatened with the loss of his best friend, Sherry retaliates, looking for anything to keep her with him, and they both embark on an emotional journey featuring a promiscuous actress, a newspaperman playwright, and two children in dire need of some help.