Sam and Dean Winchester had thought they had already defeated Lucifer and were done with the mess, but while following a trail of destruction and strange deaths, the come face to face with someone who claimed to be Satan himself. Much to the Winchesters' dismay, they must work with the devil to figure out this new mystery that has been causing problems in LA. More issues arise as time goes on, leaving the team stuck with a rich businessman said to be the Antichrist, and a puzzle box with the power to open the gates of Hell...