What If Itachi was half Senju

The Uchiha Clan were under constant prejudice and ridicule by the High council, the elders and any and all Senju or political supporters. And there was a time when the five great nations held a truce to wipe out the Uzumaki clan. In this timeline or what if Fukaku Uchiha had relations with the Uzumaki Clan survivor who would later become Karin's mother. What if she was Itachi's mother as well but then married into the clan in order to have Sasuke. How would this change the series would it be better or would it be for worse? Please read to find out.