Antibody-Antigen Docking

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Antibodies are essential recognition elements of the immune system, which bind tightly and specifically to various antigens to block their activity or to mark them for destruction. Antibodies are increasingly used as diagnostic tools and therapeutic drugs, and an important component of the antibody design/engineering process is the availability of high quality three-dimensional structure of antibody-antigen complexes. X-ray crystallography provides the most accurate and detailed data on protein structure and interactions, however co-crystallization of antibody-antigen complexes remains a major challenge, and the number of antibody structures determined in complex with their antigens is still relatively small.

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antibody-antigen docking

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Sat, Feb 8, 2020

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