A Pantologist's Meeting with an Impressive Artist

"When the time comes, the faith of the universes will rest on their shoulders."
James Iron is the kind of man who will try every single profession to satisfy himself. He wanted a job that makes him use his maximum potential. But due to his magic, he can do enormous tasks without breaking a sweat.
After his work, he sees a blue-haired girl who is an outstanding artist, equal to the most remarkable artists the world has to offer.
The destinies of those two intertwined, and their meeting will bend the fate of the universe.

But as both of them set off on a journey, unwanted dangers will pass on to the mysterious poker-faced girl.
What is their motive for killing that girl? Who even is she in the first place?