Sam Winchester loses every single person around him. He was an addict to demon blood after his self-deprecating nature caught up with him. He's been trapped in hell with Satan himself and tortured mercilessly. He's been through all of this (And a whole hell of a lot more), but kept fighting. Not for himself, but for his brother Dean and (although he didn't realize it until the blade already plunged into his back) he also fought for Gabriel. Sam is quickly losing hope and for once, Dean can't help him regain it.