Carmen Isabella Sandiego started off as a child prodigy who loved to learn and was a very smart and talented person. She was even a crime fighter with a group called A.C.M.E. (Agency to Classify and Monitor Evildoers) and was one of the top agents. One day, however, she left ACME and went into a life of crime and started the rival organization: V.I.L.E. (Villains International League of Evil). Her fall was a mystery to the Chief, Chase Devineaux, and many agents in A.C.M.E. Two new agents, Eric Clark and Carly Davis were assigned to go after Carmen and her men after another international crisis was started by Carmen when world leaders disappeared and the world economy was imbalanced. It was another race against the clock to face Carmen and V.I.L.E and this time, rules would slowly go out the window.