Cremated flower

Hanahaki disease. The disease where unrequited love (one-sided love) causes coughing up blood and flowers from your lungs (sometimes just flowers and petals) the deeper your love for them the worse the flowers become.
Hoshizora no me disease. The disease is similar to the Hanahaki disease but affects the eyes instead of the lungs. The person who's love is not returned contracts a disease where they cry so much it starts to blur their vision and freckles appear on their face. Star shaped freckles which glow at night. Eventually the disease travels to the brain and kills the host.