In a society advocating eugenics, where a virus spread by the government makes the citizens "perfect" and resistant to all kind of diseases, Amy Hadley, suffering from diabetes, is seeing as an anomaly. Despite her bullies, she joined the government's elite society, "the Global", as a doctor, in order to bring in her brother, seriously injured during the war, and in need of a transplant. She then becomes the flaw of a seemingly perfect system, and will, despite her wants, find herself at the heart of a war between a corrupt government thirsty for power, and free spirits who have made their diseases, their " genetic anomalies " the weapons of rebellion.