Following the events of Black Siren (Suicide Squad) Donna Spear broke out of the prison where she and the rest of the Suicide Squad were kept when Joker jailbroke Harley so she could return home to her daughter, Kylie Spear. Kylie Spear, being the daughter of a daughter of a metahuman, soon learns that she has the same Siren like powers that her mother Donna has. When she screams, she can kill or inflict harm, and when she sings, she can control the actions and thoughts of other people. Kylie and Donna have been on the move ever since Donna broke out of jail, and they wound up in Gotham. Donna, a close friend of Harley's, is her only friend. Kylie's only friend is Cassandra Cain, a girl that is suddenly quite important to villain Black Mask. Can Kylie and Donna work together with Harley, Dinah Lance, a cop Montoya and the Huntress, Helena Bertinelli, in order to save Cassandra and beat the bad guys?