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The journey of Vitamin B12 originated long ago in the 1820's when fatal anemia was quite common and the Nobel prize win ner Com berelates "a digestive symptom disorder with this fatal anemia" and coined later as pernicious anemia, a condition in which not enough red blood cells are produced due to a lack of Vitamin B12. The interest in understanding Vitamin B12 and its importance in healthcare domain never came to a halt to date. Thereby, the term Vitamin B12 resonates widely in the scientific community from megaloblastic anemia till Chemotherapy associated neuropathy.