After Racoon City had been sterilized and Umbrella Corps. was finished, a new terrorist organization called Neo Umbrella had unleash a powerful virus that could infect people faster than any other viruses from past several years. In 2012 the C-Virus has been unleashed in Edonia, Eastern Europe and the year 2013, a nightmare was unleashed as the C-Virus has struck the peaceful town, Tall Oaks, U.S.A, now Christa Lenz and Y/n L/n of the U.S DSO government along with Leon from the DSO also and Secret Service Agent Helena worked together to survive this worst nightmare