The tale of a young half human dog named Wilfred, whose stepmother, Jenna Mueller, is jealous of his beauty. When she sends a hitman to put an end to him, Wilfred flees to Venice Beach, where he meets the Newman family, who protect him by making him their guard dog. As Wilfred adapts to his new life and begins to fall in love with the young man, Ryan Newman, Jenna vows to do whatever it takes to be the fairest in the land.