In the year 2022, a series of cyber-attacks across Iloilo are the result of catastrophic events in another world within the internet, the Digital World. Gab, a young boy gets transported to the internet and meets Gomamon while they are attacked by a swarm of Argomon. They meet up with Brian and his partner Tentomon and together they defeat the Mega Argomon as AntarcticBeetleDramon.
While getting ready for summer camp, Gab, Brian, Peter, Jao, Gianna, Ali, and Sky are transported to the Digital World where they acquire Digivices and Digimon partners while learning that they have been chosen to stop the Dark Digimon causing attacks both the Network and the Digital World. They are lured into a fake Iloilo dimension where Eyesmon, another opponent attacks them. AntarcticBeetleDramon is able to destroy Nidhoggmon before the countdown to destroy the real Iloilo in the Real World happens.
They are joined by Cliff, on their mission to stop Devimon, an evil Digimon who rules the Cloud Continent. After Devimon's defeat, on the Eternal Continent, they are joined by Feia and her partner Tailmon, who serves as their guide to the Sealed Grounds, where Millenniummon, an ultimate weapon of the Dark Digimon, is to be revived. Unfortunately, Millenniummon's servants, Vademon and Sakkakumon were able to restore Millenniummon's body, and was unleashed in an attempt to destroy the entire Digital World, but was defeated by Vikemon with the hopes of the Digimon the Chosen Children befriended in their adventure.
After Millenniummon's defeat, all nine Chosen Children must discover the true power of the Crests in their Digivices to stop Negamon, the benefactor of the Dark Digimon and the creator of the Argomon and Eyesmon, from bringing the Great Catastrophe.
A group of girls-Sam, Delaney, Kyoi, Genevieve, and Ellie-are all given opportunities to go to the exclusive Deluxe Academy in Digitala City. However, that name is just a cover for a academy in the Digital World known as the DigiDestined Academy, where they meet and make friends with all of the DigiDestined from the past and present. They fight former Digimon villains, including Devimon, Etemon, Datamon, Myotismon, Arukenimon, Mummymon, and Diaboromon. However, the twist is, they have twice as much power! The team partners up with their Digimon-Meramon, Wizardmon, Seadramon, Sorcermon, and Elecmon-to battle these forces. And who knows what's coming next? Nothing is certain in this alternate world!