An unknown virus has been discovered by American scientist Eric Selvig. This deadly disease attacks the immune system and targets the blood stream. It spreads like wildfire and kills even faster. People have begun to look towards S.H.I.E.L.D. for answers and protection. Hoping to eliminate the panic, they call in Bruce Banner and Tony stark. Although neither of the two specify in infectious diseases, they are the two most qualified scientists SH.I.E.L.D. has at their disposal. Will they figure out how to stop the virus, or will they be next to join the millions of people dead and infected?