In 1899 ad, a virus was spread throughout the land of Qixingyu. It makes a tiny crush develop into a huge affection or if too much, obsession. A carrier can transmit the disease by showing affection towards his or her target (e.g, hugging, kissing, love-making). The people named it Cœur de Maladie, meaning, The Love Virus.
Kawaguchi Yurina, a daughter of the most noble family in Kawaguchi Prefecture, Japan came to visit the country of Qixingyu before the virus had broken out. She finds the crown-princess very attractive. Yurina tried her best to hide her feelings, and succeeded as no one had ever found out about her secret fantasy, except for the Enchanted Lady in the lake near the Palace.
And then we have Shen Xiaoting, a stoic woman, crown-princess of the Qixingyu Dynasty. She had never loved anyone, nor felt love herself. Her mother, the Queen Consort had passed long before she could remember, and her father, the King had payed her no attention. The virus wouldn't work for her, as she hasn't found anyone attractive other than herself.
The spreading of Cœur de Maladie had badly affected the royal family, and the walls they had built to keep the rampaging people out of the castle are on the verge of crashing down. What's worse is that the King seemed to be infected and is hitting on almost all of the consort inside the palace. Xiaoting, being the only sane royal, decided to look for the solution herself. With the help of her newly found assistant, Kawaguchi Yurina.