Cal Lynch travels back in time to 15th-century Spain through a revolutionary technology that unlocks the genetic memories contained in his DNA. There, he lives out the experiences of Aguilar de Nerha, a distant relative who's also a member of the Assassins, a secret society that fights to protect free will from the power-hungry Templar Order. Transformed by the past, Cal begins to gain the knowledge and physical skills necessary to battle the oppressive organization in the present.