depression noun UK /dɪˈpreʃ.ən/ US /dɪˈpreʃ.ən/ depression noun (UNHAPPINESS) B2 [ U ] the state of feeling very unhappy and without hope for the future: I was overwhelmed by feelings of depression. - - - - - - - I cannot quite pinpoint the date depression creeped up outside my door ready though uninvited, but one thing is sure; I haven't felt nothingness so vividly in my life since the moment it knocked its small, vicious hands on my little heart's door. A tragedy, a letter, a story. (This story contains mentions that could possibly trigger some readers. Please read the tags before reading the novella)