The osler medical handbook -john hopkin

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Section VIII&nbsp;–&nbsp;Infectious Diseases
    
    
    
    Section Editors:
    Christopher&nbsp;Hoffmann,&nbsp;MD, MPH&nbsp;&nbsp;&nbsp;Nicola&nbsp;Zetola,&nbsp;MD
    
    
    Chapter 53&nbsp;–&nbsp;Fever of Unknown Origin
    Scott&nbsp;Kim,&nbsp;MD&nbsp;&nbsp;&nbsp;Rachel&nbsp;Damico,&nbsp;MD, PhD&nbsp;&nbsp;&nbsp;Paul&nbsp;Auwaerter,&nbsp;MD
    
    FAST FACTS
    &nbsp;&nbsp;	▪&nbsp;&nbsp;&nbsp;	The contemporary understanding of fever of unknown origin (FUO) is derived from Petersdorf and Beeson's 1961 characterization of FUO. A stringent definition of FUO is composed of the following criteria[1]: temperature higher than 38.3° C measured on several occasions, 3-week duration (to exclude self-limiting fevers), negative blood cultures, no apparent explanation, and three outpatient visits or three hospital days.
    &nbsp;&nbsp;	▪&nbsp;&nbsp;&nbsp;	Infections, malignancies, and noninfectious inflammatory diseases account for the majority of cases of FUO.
    &nbsp;&nbsp;	▪&nbsp;&nbsp;&nbsp;	In patients older than 65 years, temporal arteritis should be considered early in any evaluation.
    &nbsp;&nbsp;	▪&nbsp;&nbsp;&nbsp;	Patients with FUO who remain undiagnosed after exhaustive study usually have a favorable prognosis. In one study, in a cohort of 61 patients with FUO discharged without diagnosis, the 5-year mortality rate was only 3.2%.[2]All Rights Reserved

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infectious diseases
Tue, Jan 20, 2015

Section VIII&nbsp;–&nbsp;Infectious Diseases
    
    
    
    Section Editors:
    Christopher&nbsp;Hoffmann,&nbsp;MD, MPH&nbsp;&nbsp;&nbsp;Nicola&nbsp;Zetola,&nbsp;MD
    
    
    Chapter 53&nbsp;–&nbsp;Fever of Unknown Origin
    Scott&nbsp;Kim,&nbsp;MD&nbsp;&nbsp;&nbsp;Rachel&nbsp;Damico,&nbsp;MD, PhD&nbsp;&nbsp;&nbsp;Paul&nbsp;Auwaerter,&nbsp;MD
    
    FAST FACTS
    &nbsp;&nbsp;	▪&nbsp;&nbsp;&nbsp;	The contemporary understanding of fever of unknown origin (FUO) is derived from Petersdorf and Beeson's 1961 characterization of FUO. A stringent definition of FUO is composed of the following criteria[1]: temperature higher than 38.3° C measured on several occasions, 3-week duration (to exclude self-limiting fevers), negative blood cultures, no apparent explanation, and three outpatient visits or three hospital days.
    &nbsp;&nbsp;	▪&nbsp;&nbsp;&nbsp;	Infections, malignancies, and noninfectious inflammatory diseases account for the majority of cases of FUO.
    &nbsp;&nbsp;	▪&nbsp;&nbsp;&nbsp;	In patients older than 65 years, temporal arteritis should be considered early in any evaluation.
    &nbsp;&nbsp;	▪&nbsp;&nbsp;&nbsp;	Patients with FUO who remain undiagnosed after exhaustive study usually have a favorable prognosis. In one study, in a cohort of 61 patients with FUO discharged without diagnosis, the 5-year mortality rate was only 3.2%.[2]

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