La Première Dame takes place in an alternate universe from the original Black Panther film and the original Kompound universe created. In this universe, Erik only has 5 wives, and Hennessy's upbringing is drastically different. La Première Dame follows Hennessy's life as she grows from gifted child prodigy to free spirited artist and marijuana dealer and finally to one of five Princesses of the wealthiest nation in the world.