Jane Rizzoli is a former a detective with the Boston Police department homicide division works with very supportive team and is married to her long time childhood friend, Dr. Maura Isles. Jane is now a well known International Criminal lawyer who speaks several and writes as well. Maura is the Chief Medical forensics Examiner of the Sheriff's of Sacramento County. They have their ups and downs in their careers, family and personal life. What will these two and their loved ones get involved and do now?