Annie, Tori, and Chloe live their lives in a tedious routine when a strange occurrence brings the villainous team leaders from the Pokémon games into the real world. Annie attempts to befriend and help them, Tori keeps her eye on their strange behavior, and Chloe does her best to uncover the truth about this strange phenomenon. Their home becomes a chaotic mess now that Giovanni, Archie, Maxie, Cyrus, Ghetsis, Colress, Lysandre, Guzma, and Volo have been thrown into their world. How will three women navigate and reign in the ensuing disaster?