The Wise Old Crab has found out about a prophecy that foretells the end of the world in an ancient book he found. Jimmy Neutron notices that giant orange meteors are crash landing in Retroville, the Wise Old Crab tells Jimmy about the prophecy. Jimmy tells him that he's going to get the team back together, but adds "We're going to need all the help we can get."
Meanwhile, on a seemingly normal day in Bikini Bottom, SpongeBob and Squidward are on their way to work when the same huge asteroids start raining down on Bikini Bottom and orange creatures take over. Jimmy Neutron then arrives to take Spongebob and Patrick to Volcano Island.
SpongeBob, Patrick and Jimmy then arrive at the Mawgu Lair, where they meet up with Danny Phantom, Tak, Timmy Turner, Jenny Wakeman, Izuku Midoriya (accompanied by 5 of his classmates), and the new "Evil Syndicate" composed of Technus, Beautiful Gorgeous, Traloc, Vexus, Vicky and Plankton, along with Zim, Dib, Shaggy Rogers, Scooby-Doo, Sonic the Hedgehog, and Dr. Eggman offering to help. Together they make a plan to travel and battle their way through their home worlds in order to stop the gooey creatures, save their friends, and find out who's behind it all.