Six years have passed since the viral outbreak in Raccoon City. The Umbrella Corporation has gone bankrupt due to a crash in stock sales after it is revealed that they are to blame for the incident. Two of the few survivors, Leon S. Kennedy and his wife Maddie D. Kennedy, has been trained by U.S. Special Forces to protect the President of the United States and his family. Their first day on the job, they are sent to a remote location in Europe to retrieve the President's daughters, Ashley Graham and Abigail Graham. Awaiting Leon and Maddie are a slew of unspeakable creatures, a "curse" that attacks the body, rendering the victim powerless to the control of sadistic, inhuman forces that would destroy everything Leon and Maddie hold dear. Now, they must rescue Ashley and Abigail and uncover a plot that could lead to ultimate global destruction. Their time is running out, and a few familiar faces may well be their undoing.