In a different Earth, far removed from the one we know, the webs of destiny were entwined in a unique pattern. Miguel O'Hara, the Spider-Man of 2099, found himself and the Spider Society caught in a cross-dimensional crisis.
Desperate to restore order to the Spider-Verse, Miguel recently discovered whispers of twin siblings, Peter and Penelope Parker, who possessed extraordinary powers. They were known as the Spiderman and Spiderwoman of their Earth, and rumors spoke of their incredible potential. Miguel believed that these siblings held the key to fixing the shattered multiverse.
Meanwhile, on Earth-818, Estella Stark, the eldest daughter of Tony Stark and a supernatural witch, and Harley Keener, her closest ally, watched over the twins and their younger sister, Morgan. Estella, having inherited her father's genius and her mother's mystical gifts, had taken on the mantle of guiding the Parker siblings and protecting their Earth.