Creatinine levels that increase are known to damage kidneys There are a variety of side effects of high creatinine that include: 1. The cause of dehydration is due to a higher amount of creatinine present in the kidneys. Additionally, it decreases circulation of blood to the kidneys. 2. It can cause kidney infection. 3. the breakdown of muscle happens when high levels of creatinine are taken up by the kidneys. 4. Creatinine levels that are high can also lead to kidney damage as well as a variety of kidney disorders. If the kidneys aren't functioning properly, the creatinine levels build into the bloodstream, and levels rise. It is detected through kidney diagnosis. The cause can come from different causes, for example: 1. Kidney disease: It's the most common reason for excessive creatinine. The chronic kidney condition, acute kidney injuries, glomerulonephritis and kidney infections may affect kidneys' ability to remove out waste efficiently. 2. The lack of adequate fluid intake may cause a slight rise in the levels of creatinine. The dehydration process reduces the flow of blood to kidneys and can affect their ability to filter fluids. 3. The kidneys can be affected by medications and can cause increased levels of creatinine.