When Damien Calloway, the Alpha of the North American Association of Werewolves, doesn't call back a vengeful Cecilia Vaughn after sleeping with her, he comes to regret it. He wakes a week later with everything in absolute chaos as the entire werewolf community has been turned into humans and he is blamed for the curse. As the Werewolf Elders try to work it out with Cecilia and her family, everyone is seriously upset at their former alpha. The Elders and the Were community stick Damien out on his ass to try and figure out how to break the spell before they are all wiped out by a greater threat. Throw in some Norse mythology and it becomes a whirlwind of chance and pandemonium. This is the story of how the once mighty alpha became human and possibly back again.
This kind of thing only happens once in a blue moon.