In "Daria and the Multiverse Mischief," Daria and Jane find themselves in a parallel universe where characters from various TV shows, movies, and books coexist. Teaming up with unlikely allies like Buffy, Sherlock, and the Doctor, they discover that an omnipotent entity called the "Crossover Conductor" is responsible for the chaos. With Daria's deadpan wit and Angel's brooding introspection, they confront the Conductor, urging it to find purpose within itself. After a climactic showdown, the multiverse is restored, and Daria and Jane return to their Lawndale, armed with a new appreciation for the quirky adventures that define their reality.