Zack and Kelly Morris are still married. They live in a beautiful suite at the Planet Hollywood Hotel in Las Vegas. Zack teaches guitar at a local music store. Kelly works from home as a hotel therapist. Unfortunately, there is trouble in paradise. For 3 years, Zack and Kelly have been trying to have a baby. So far, nothing seems to be working. The struggle to start a family has taken a huge toll on Zack. In an effort to save her marriage, Kelly convinces him to come with her back to California to attend their high school reunion. There, Zack and Kelly are reunited with their friends, Lisa, Jessie, Slater, and Screech. Turns out, this is the first time the gang has seen or talked to each other in years. Can they still be "friends forever?"