Nang ipinanganak sila ay itinadhana na silang maging matalik na magkaibigan habambuhay. Priel and Maeve were inseparable; they shared every secret, every laugh, and every tear. Mula elementary hanggang sa pagtapak nila ng kolehiyo sa University of Santo Tomas ay hindi sila nahiwalay. Ngunit habang tumatagal, unti-unting lumalalim ang kan'yang nararamdaman para sa kan'yang matalik na kaibigan. Threatened by Maeve's growing feelings towards her best friend, she decides to make a bold decision to confess, but not to be reciprocated, rather, to introduce her plan called "Operation: Unloving You," hoping to extinguish the flames of desire that had been burning within her for so long. With Priel's agreement, will they succeed with "Operation: Unloving You" and return typically as friends, or will their desires blur the lines of their friendship?