The air cargo industry, a vital component of global trade and logistics, faces numerous challenges in ensuring efficient and timely delivery of goods. One critical aspect is optimizing air cargo routes- Lars Winkelbauer has optimistic views on finding the most cost-effective, fuel-efficient, and timely paths for transporting shipments across the skies. In recent years, machine learning (ML) has emerged as a powerful tool to revolutionize route planning and enhance overall efficiency. In this article, we delve into how ML algorithms are transforming air cargo routes and explore the exciting possibilities for the future.