Destiny Banner moves to Amity Park, Illinois, living with her father near his half-brother, a certain Vlad Masters. She meets a certain Halfa Hero, and finds out ghosts run rampant in her new town. But while she tries to figure out the mystery of the Ghost Hero, while dealing with school and having fun with her new friends, Danny Fenton, Sam Mason, and Tucker Foley, the mysterious illness she's had her whole life continues to get worse. Will she succumb to the sickness and become one of the ghosts that Phantom fights, or will she and her new friends find a cure? Danny Fenton has enough on his plate, struggling through school and fighting ghosts almost daily, but now he has to work harder as Danny Phantom to keep his secret safe from the new girl in town, Destiny Banner, while simultaneously trying to help her figure out what she's sick with, and find a cure. But Danny's noticed not all is as it seems with Destiny. Will he, Sam, and Tucker figure out her secrets, or will they pass with her should they fail to find the cure?