The Patient-Derived Tumor Xenograft (PDX): model is established by directly transplanting the patient's tumor tissue into immunodeficient mice. The characteristics of most primary tumors in histopathology, molecular biology and gene level, ensuring relatively reliable predictions of clinical efficacy . Therefore, the platform is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.
When Jane Madarang's neighbor Natalie kills herself and leaves behind cryptic instructions, it's up to Jane and her classmates to unearth deadly secrets.
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Natalie Driscoll is dead.
She threw herself out a window and left her neighbor Jane to unravel their town's darkest secrets. Following Natalie's instructions leads Jane to three other high school students who all have something to hide. The four of them must carry out Natalie's final errand while solving the mysteries written in her diary. But the secrets they unearth may be far more dangerous than what they ever imagined.
Content and/or trigger warning: This story contains scenes of suicide, violence and murder that may be triggering for some readers.
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