Charlie Swan, John Winchester, and Noah Stilinski. Half brothers, who all went vastly different paths when they grew up.
Charlie Swan stayed in Washington, married Renee, it was familiar and his home. His daughter became a vampire, not that he was fully aware of that.
John Winchester married Mary, then when she was killed he became a hunter. Raising his two sons that way. Hunting the exact thing his niece was.
Noah Stilinski moved to California, married Claudia. When she died, he raised Stiles on his own. His son becoming friends with werewolves, and other supernatural alike.
All different, different paths, different lives, but all tied together by the supernatural community.
What happens when they meet again many years later?
All under...odd circumstances.
I own non of these characters, all belong to their respective creators!